Is it on-line or OTB?
How would the software be handling touch move?
If a piece can be dragged around the board until it is dropped then the position is available for analysis (similar to hanging onto a piece on a new square but not releasing) and if that piece can be returned to its square and subsequently another piece chosen to make that move then that would allow one-half-move visual analysis for all pieces. If the tournament is using on-line ratings then that is not an issue. If the tournament is using OTB ratings then the lack of being able to make a touch move claim is a difference. I always felt that two significant reason for the OTB touch move rule were (1) moving various pieces on the board is a distraction to the opponent (not applicable when the opponent doesn’t even see such moves) and (2) moving various pieces risks not every piece being returned to its home square before moving another and thus multiple moves being made at once (not applicable when the computer limits it to one move at a time). With the touch move change affecting all players equally, and the automatic avoidance of those two significant reasons, I don’t see it as an insurmountable barrier to OTB rating it.
The prevention of illegal moves (and the lack of being able to claim them) is also kind of a difference, but only kind of because the main rule is for the TD to have all illegal moves corrected before play continues. Very few people realize that is the main rule because of how often the small-TD-to-player-ratio variation is used (where the player must first make the claim). The computer would be providing the unbiased monitoring to enforce illegal move correction and do it equally for everybody. This is not a barrier to OTB rating it.
The flag would be called by a non-player but the non-player is neutral. This is a semi-plausible argument against OTB rating it.
Two-dimensional and three-dimensional viewing can affect players differently. Being blindsided by a radically different format could adversely impact the playing ability of somebody who wouldn’t have come if the format had been known. This is a plausible argument against OTB rating it.
Conclusion: If the conditions are announced in all advance publicity then it is an acceptable major variation and OTB-ratable.
If the conditions are not announced in advance then it is begging for an appeal to the Rules committee and having some physical boards&clocks for players that don’t want to use the unexpected screens would help avoid such an appeal (this would be a return to a no-computer sign up sheet so that players would be able to avoid being browbeaten or shamed into giving in to playing in an unwanted on-line-like manner).
PS Touch move claims would go down. Claims of distracting the opponent would go down. Claims of interference/assistance might very well soar. TDs wouldn’t have to monitor time pressure blitzes and would be able to focus even more on watching for assistance.